Project manager:
Dr. Med. vet. Ingo Nolte
Dr. Nat. Sci. [rer. nat.] Holger Lubatschowski
Dr. Med. Christian Junghanß

Cell-based vaccination strategies with dendritic cells (DC) loaded with tumour antigens which have been differentiated from hematopoietic stem cells or monocytes, are being evaluated currently both in preclinical as well as first clinical studies and have made the induction of specific immune reactions possible.

Project manager:
Dr. Med. Thomas Lenarz
Dr. Nat. Sci.[rer. nat.] Doris Klee
Dr. Nat. Sci.[rer. nat.] Wolfgang Ertmer

In industrial nations, approx. 12 % of the population suffers from a hardness of hearing needing treatment. The large majority of them show sensorineural hearing impairment. The cause is damage to the outer ear and with a high degree of hearing loss, also to the inner hair cells. With conventional hearing aids and implanted hearing aids coupled to the ossicular chain or the perilymph, it is only partially possible to compensate for this functional failure through preprocessing and amplification of the acoustic input signal because the amplifier and filter function of the outer hair cells cannot be replaced in this way.

Project manager:
Dr. Nat. Sci. [rer. nat.] Boris Chichkov
Dr. Med. Gustav Steinhoff
Dr. Med. Peter M. Vogt

The Tissue Engineering of replacement tissue and organs is a central subarea of regenerative medicine. Particularly interesting is here the production of autologous tissue with full functionality. For this, cells must be arranged in complex three-dimension (3D) matrices in order to replicate the tissue in its natural microstructure as closely as possible. In this subproject, the laser-induced forward transfer will be used and further developed in order to arrange cells and biological active agents together with a matrix having the highest precision layer for layer 3D. The application for this will be found in the generation of artificial skin replacement especially with severe burns and in the production of cardiac patches for the regeneration of myocardial infracted tissue.